![]() The genetic disorder McCune-Albright syndrome can also present as Cushing's syndrome in affected patients. Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. In certain animals such as rodents, the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol. The main source of androgens will come from the zona reticularis region. The zona fasciculata also generates a small amount of weak androgens. Cortisol enhances the activity of other hormones including glucagon and catecholamines. ![]() This layer is responsible for producing glucocorticoids, such as 11-deoxycorticosterone, corticosterone, and cortisol in humans. Glucocorticoid production is stimulated by adrenocorticotropic hormone, which is released from the anterior pituitary, especially in times of stress as part of the fight-or-flight response. Zona fasciculata is the layer situated between the glomerulosa and reticularis. that the cells of the zona glomerulosa and fasciculata externa are more active than those. The zona fasciculata chiefly produces glucocorticoids, which regulate the metabolism of glucose. This content decreases gradually toward the zona reticularis. Constituent cells are organized into bundles or "fascicles." Small cells arranged into small rounded groups or curved columns. The zona fasciculata constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa. zona glomerulosa (about 15) zona fasciculata (about 75) zone reticularis is (about 10) Zona Glomerulosa.
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